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⚖️ Exam Differentiation Tables

Side-by-side tables of the look-alike pediatric conditions the exam deliberately confuses, each ending with the single clue that separates them.

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Croup vs epiglottitis vs tracheitisStridor in the febrile or choking child FREERespiratory
ConditionPictureClue / X-rayAction
Viral croup (parainfluenza)6 mo–3 y, coryza then barking cough, hoarse, worse at night, non-toxicSteeple sign (X-ray not needed)Oral dexamethasone 0.15–0.6 mg/kg; nebulized adrenaline if stridor at rest
Spasmodic croupSudden nocturnal, afebrile, no prodrome, recurrent, atopic childResolves in hoursReassure; treat as croup if needed
Epiglottitis (Hib, unimmunized)Sudden high fever, toxic, drooling, tripod, muffled voice, no barkThumb signDo not examine throat or lie flat; airway in theatre, then ceftriaxone
Bacterial tracheitis (S. aureus)Viral croup then high fever, toxic, brassy cough, can lie flatNo response to adrenaline; ragged tracheal marginIntubation + anti-staph antibiotics
Retropharyngeal abscess<5 y, fever, neck stiffness/refuses extension, droolingWidened prevertebral soft tissueCT, IV antibiotics ± drainage
Foreign bodySudden choking, afebrile, 6 mo–3 yUnilateral wheeze, air trappingRigid bronchoscopy

Westley score (calculator) grades croup severity.

Toxic child + croup-like cough that does not respond to nebulized adrenaline = bacterial tracheitis; toxic + drooling + no bark = epiglottitis.
Bronchiolitis vs asthma vs pneumoniaThe wheezy or tachypneic infant/child FREERespiratory
BronchiolitisAsthma / viral wheezePneumoniaForeign body
Age<2 y (peak 2–6 mo)Any; asthma usually >5 yAny6 mo–3 y
OnsetCoryza 2–3 days, first episodeRecurrent, triggers, atopyFever, coughSudden choking
ChestWheeze + diffuse fine cracklesBilateral wheeze, prolonged expirationFocal crackles, bronchial breathingUnilateral wheeze/↓air entry
FeverLow/noneUsually noneHighNone
BronchodilatorNo benefitRespondsNoNo
CXRNot routine (hyperinflation)Not routineConsolidationAir trapping on expiration
TreatSupportive: O2 if SpO2 <90–92%, feedsSABA, steroidsHigh-dose amoxicillinRigid bronchoscopy

WHO tachypnea: <2 mo ≥60, 2–12 mo ≥50, 1–5 y ≥40/min.

First wheezy episode with coryza and crackles in an infant = bronchiolitis: no salbutamol, steroids, antibiotics or routine CXR.
Sore throat: strep vs EBV vs othersExudative tonsillitis look-alikes FREEInfectious Diseases & Vaccines
CauseDiscriminating clueTest / action
Group A strep5–15 y, sudden fever, tender anterior nodes, exudate, palatal petechiae, no cough/coryza, ± sandpaper rashRADT (culture if negative in children); penicillin V/amoxicillin 10 days
EBV mononucleosisAdolescent, posterior cervical nodes, splenomegaly, fatigue, rash after amoxicillinAtypical lymphocytes, Monospot (false-negative <4 y); no contact sports ≥3–4 wk
AdenovirusPharyngitis + conjunctivitis + feverSupportive
DiphtheriaUnimmunized, grey adherent membrane that bleeds, bull neckAntitoxin + erythromycin/penicillin
Herpangina (Coxsackie A)Vesicles/ulcers on posterior palateSupportive
HSV gingivostomatitisAnterior ulcers + swollen bleeding gumsOral acyclovir if early
Peritonsillar abscessTrismus, uvula deviated away, hot-potato voiceDrainage + antibiotics

McIsaac score (calculator) estimates GAS probability; in children it guides testing, not empirical treatment.

Exudative tonsillitis + posterior nodes + splenomegaly = EBV; amoxicillin causes a rash — do not treat as strep.
Periorbital vs orbital cellulitisSwollen red eyelid Infectious Diseases & Vaccines
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Viral exanthems and scarlet feverSeven rashes the exam swaps Infectious Diseases & Vaccines
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Kawasaki vs scarlet vs measles vs MIS-CFever + rash + red eyes/mouth Cardiology
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CSF patterns in meningitisBacterial vs viral vs TB vs HSV Infectious Diseases & Vaccines
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Physiological vs pathological jaundiceWhen neonatal jaundice needs work-up Neonatology
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Breastfeeding vs breast-milk jaundiceTwo unconjugated jaundices of the breastfed baby Neonatology
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Biliary atresia vs neonatal hepatitisConjugated jaundice in the infant GI & Hepatology
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Caput vs cephalohematoma vs subgalealNewborn scalp swellings Neonatology
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TTN vs RDS vs MAS vs pneumoniaNeonatal respiratory distress Neonatology
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Gastroschisis vs omphaloceleAbdominal wall defects Surgery & Orthopedics
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Pyloric stenosis vs malrotation vs atresiaVomiting in the neonate and young infant Surgery & Orthopedics
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Intussusception vs Meckel vs other GI bleedsAcute abdomen and rectal bleeding in young children Surgery & Orthopedics
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Hirschsprung vs functional constipationNeonatal and childhood constipation GI & Hepatology
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Celiac vs CMPA vs lactose intolerance vs CFChronic diarrhea and malabsorption GI & Hepatology
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Cyanotic congenital heart lesionsTOF vs TGA vs tricuspid atresia vs TAPVR vs truncus Cardiology
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VSD vs ASD vs PDA vs AVSD vs coarctationAcyanotic lesions by murmur Cardiology
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Innocent vs pathological murmurCan I reassure this murmur? Cardiology
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Nephrotic vs nephritic syndromeEdema vs hematuria-hypertension Nephrology, Fluids & Electrolytes
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PSGN vs IgA vs HSP nephritis vs AlportCauses of glomerular hematuria Nephrology, Fluids & Electrolytes
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HSP vs ITP vs HUS vs leukemiaPetechiae and purpura in a child Hematology & Oncology
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Iron deficiency vs thalassemia trait vs ACDMicrocytic anemia Hematology & Oncology
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Spherocytosis vs G6PD vs sickle cellHemolytic anemias Hematology & Oncology
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Hemophilia vs von Willebrand vs othersReading the coagulation screen Hematology & Oncology
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Simple vs complex febrile seizureAnd when to suspect meningitis Neurology
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Absence vs focal seizure vs daydreamingThe staring child Neurology
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Epilepsy syndromes of childhoodWest vs Lennox–Gastaut vs JME vs centrotemporal Neurology
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Seizure vs mimicsBreath-holding, syncope, night terrors Neurology
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DKA vs HHSHyperglycemic emergencies (ISPAD 2022) Endocrinology & Diabetes
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Type 1 vs type 2 vs monogenic diabetesClassifying the diabetic child Endocrinology & Diabetes
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Short stature: familial vs constitutional vs pathologicalGrowth velocity and bone age decide Growth, Development & Nutrition
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Central vs peripheral precocity vs benign variantsEarly puberty signs Endocrinology & Diabetes
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Central vs nephrogenic DI vs polydipsiaPolyuria and polydipsia Endocrinology & Diabetes
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DDH examination by ageOrtolani, Barlow, Galeazzi and imaging Surgery & Orthopedics
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Limping child: synovitis vs septic hip vs Perthes vs SCFEHip pain by age Surgery & Orthopedics
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Acute scrotum: torsion vs appendix testis vs epididymitisThe painful or swollen scrotum Surgery & Orthopedics
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Atopic vs seborrheic vs napkin rashesInfant eczematous rashes Dermatology
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Abuse vs accidental injuryRecognizing non-accidental injury Emergency, Toxicology & Resuscitation
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Wilms tumor vs neuroblastomaAbdominal mass in a child Hematology & Oncology
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Trisomies vs Turner vs NoonanDysmorphic syndromes the exam pairs Genetics, Syndromes & Metabolism
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